PoE Pathfinder builds without Detonate Dead of Chain Reaction, Penance Brand of Dissipation, Toxic Rain

Hey there, weary exile. I hope you're as hyped for league start as i am. I've thought about league starting Poisonous Concoction Pathfinder, and came up with this PoB. I'm wondering what you guys think, and if there's a better angle to approach it. Damage seems to be okay (?) if calculating with the 300% increased damage mastery and an conservative approach of 3 poison hits/"shotgunning". 36k Poison DPS \ 3 \ 3 = 342k DPS 133k Total Damage Per Poison (3.6s duration) \ 3 \ 3 = 1.2m DPS My defenses however, are all

The build is just a rough idea, it is nowhere near min-maxed. But the number seems promising so I decide to share it :) pob with quite endgame gears: dps while focused: 13m x 2 (helix hits twice in close range) Defense: 4.5k life, 46k evasion, 100% spell suppression, +216% ms (with QotF), purity of element for ailment immunity. Hopefully it's enough to survive most of the contents. I generate Endurance/Frenzy/Power charges by using Doedre's Elixir. With the reworked Survival Instincts jewel (50% chance not to consume charges), it should be sustainable. Flat

Looking for some discussion on this theorycraft and its potential as a league starter. PoB: For the most part, this is a fairly typical Poison Pathfinder build. In that sense, I think this (or any other Poison) build will do well at league start. Especially so with the new Mastery node for Poison that grants 300% increased damage on first application. I've also looked into some synergies for this build to grow into that I'd like to discuss. Lethe Shade Lethe Shade seems like a fairly mediocre node which gives a small upside

BIGGEST PROBLEM: SUSTAIN LIFE FLASK CHARGES DURING BOSSING ??? Attack damage = physical damage?

super super rough PoB (especially considering changes coming): 3.16 i'm gonna be making an MFinder just for the fun of it and so am having to build around all of the uniques. it's pretty restricting. there's almost no flat life or resistances on the gear (didn't want to put in some PoB ventors) and so am building around that with a super passive playstyle (bow and ballistas) and lots of jewels on the tree. but also damage itself has been a question for me, especially as i don't really trust my capacity to get an honest readout from PoB with all the moving part

PoB: First time playing HC, so don't really know how to balance defence/offence. Defence layers: Acrobatics + Elusive (Nightblade/Withering Step) + Vaal Grace for Dodge Mistwall for Block Wind Dancer + Petrified Blood (Full Life) for 1-shot prevention Skitterbots for Chill Defiance Banner Fortify on Whirling Blades Permanent Topaz/Sapphire/Ruby Flasks (can be automated with Instilling Orbs) Positive Chaos Res Lvl 20 CwDT with Steelskin Near-permanent Life Flask restoring 2k Life/s Endurance charges from Sy