Here's the PoB: https://pastebin.com/BRR5yjAx.

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As for why I chose zerker, the ascendancy offers 68% AS, 20% MS, 40% more damage, and instant 25% HP heals every ~1.8 seconds. The 10% HP degen can most likely be countered by regen from the tree, Enduring Cry (with 3 second duration), and Thief's Torment + Quill Rain + hella AS (~6.8 AS + Mirage Archer). Temporal Chains and Toxic Rain's slow helps with defense as well. Overall, Berserker offers some nice utility, and tons of damage and AS, and a pretty decent spot on the tree.

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As for the tree itself, I went for a lot of life to compensate for degen (213% with Might of the Meek) and made my way to the Ranger/Shadow area for some of the DoT nodes and Acro/Phase Acro.

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As for gear, Quill Rain probably beats a +3 bow for TR and most of the gear can be filled out with rares. Kaom's is a great chest (as usual) that allows you to break 8k life without too much effort. Cherrubim's gives a lot of damage and good life and is a great SC option. Thief's Torment gives a nice amount of res (although capping is already ez) and insane sustain with +50 life on hit and +30 mana on hit, which synergizes really well with the build. Windshriek is a decent set of boots (MS and res) and lets you go dual curse (temp chains and witchfire despair). Warped Timepiece is possibly a strong option as it gives AS and skill effect duration.

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As for gem setups, a CWDT IC paired with Inc. Duration and Enduring Cry is solid (and you can get long ICs with Endurance Charges), Blasphemy Temp Chains (both with quality) paired with Enhance gives fat slows, and sticking that with Phase Run in a 4L gives you extra MS (and Phase Run is nice MS already and phasing in delves). One 6L can be used for Toxic Rain, and if you're not running Kaom's, a 6L Caustic Arrow might be decent as supplementary ST. Withering Touch Toxic Rain RAT seems like a solid option in theory, as well.

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Any feedback would be really nice, I'm not sure how optimized the tree or the rest of the build is.

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Edit: 6L might be better used with Blink Arrow and possibly Herald of Agony as we only reserve 40% mana (if using Witchfire Brew).