I have created a build guide on the official forums showcasing two "sacrifice" effects: the new Sacrifice Support gem introduced in 3.22 and 100% energy shield sacrifice from "Everlasting Sacrifice." The result is an exceptionally tanky and fast Pathfinder capable of speed-mapping, Sanctums, Maven invitations, and Uber bosses.

The build revolves around spending a portion of life to add flat damage to a self-cast Hexblast. The flat added chaos damage results in large ignites (with 100% chance to ignite from gear and the tree). The build quickly recovers the sacrificed life by leveraging Pathfinder's "Master Surgeon." Using the unique ring Blackflame, damage is scaled with wither through the Pathfinder's other ascendancy notable "Nature's Reprisal" and the use of a Despair curse aura. Ball Lightning is used to apply wither stacks and ensure the enemy always remains ignited so that wither stacks do not expire.

Using the combination of Mahuxotl's Machination and a Replica Sorrow of the Divine, I was able to achieve 100% uptime on "Everlasting Sacrifice" making my maximum fire and chaos resistances 88 and 86%, respectively. All lightning and cold damage is shifted to fire and chaos using Mahuxotl's and a "Tempered by War" timeless jewel, meaning I don't have to build for lightning or cold resistances at all. This frees up space for stats in my gear suffixes, making room for a large number of tattoos on the passive tree. I convert travel nodes to % life to further increase the damage (due to Sacrifice support) and tankiness of the build.

All together, the build has huge max hits at 75k/71k/38k elemental/chaos/physical, >2,000 HP recovery per second, +130% unconditional movement speed, and ~4.5M pinnacle ignite DPS.

If you're interested, my forum guide has a very detailed description of the mechanics, gear selection, etc. I appreciate all of your comments.

Here are some showcases of the build at work: T16 quick map with Maven witness Level 83 Lycia High quant Maven invitation Tanking Sirus mechanics

Path of building: https://pobb.in/UOtwL27tnWVp