Been playing this since the start of the league, went trough many iterations. Reached 99, can do and did all content, strong from start to finish.
Current PoB: https://pobb.in/qHEWk1VtjX-W Boss showcase (note: some at earlier build stages and don't vaporize em' instantly)
Uber Sirus
Uber Duber Elder
"Low" budget Feared
"High" budget Feared
Simu 28-30
Elderslayers Invite
Uber Exarch
Uber Maven
Main takeaways:
Omni is overrated
...at least for my build. PoBed it multiple times and it always ends up as merely an expensive damage sidegrade.
Melding is not overrated
...it's OP.
Learn to love Grasping Vines
Natural Affinity is a really strong bossing jewel, I was aiming for The Interrogation but was crit capping without brittle and trading shock & freeze for scorch didn't feel worth. Defo not everyone's cup of tea tho.
March of the Legion
PSA: Make sure you're reliably getting all 3 resonance types, I see a lot of people's builds using Anger Blessing in a way that they'll never have other element hit harder than fire, losing out a whole link worth of damage
These boots are GOAT for this build, it allows the QoL of being able to trigger adrenaline with 1 cast of blessing, roughly 35% more damage from gem levels and being able to add empower, higher if you corrupt gem levels.
Fatal Flourish forbs
If you can stomach ditching Multistrike, this new addition gives you some Giga Deeps. Multistrike can't support Vaal skills, but that doesn't mean Vaal skills can't repeat. VLS becomes something truly glorious with it.

Best of all, it was super cheap to get off the ground and it's "finished" state cost me only ~60ex. It could do most content already on a shoestring budget, the $ just elevated it to comfortable and deathless uber/sim/juiced level.