https://pastebin.com/wBcfk6Vi
So with the release of the 'monsters deal 25% less damage, 50% more life' I think Assassin benefits more than anyone, especially because Opportunistic grants -20% less dmg taken when 2+ rares around, and 8% less from Infusion results in enemies doing 0.55x the damage.
I somehow got 400k sirus DPS with severe restraint in terms of the items I chose not even counting the release wave damage. Scorching.
This is obviously a template and not a full build but I'm surprised at how good the numbers look on this. Comments welcome.