Theorycrafted a Poison build centered around Binos for prolif, elusive stacking for efficient dps scaling and assassin to complement both the efficient poison scaling and the elusive effect.

This is not the absolute starter setup, more the red map follow up version.

League start would likely include sword mastery for frenzy instead of redeemer chest, no thread of hope and rare jewels but instead crit grand spectrum, dropping some crit nodes in order to fund the pathing to the ranger life nodes.

https://pastebin.com/9AJEuu02

Things I don't know how they turn out: mana sustain (especially pre thread of hope), general survivability, helix playstyle without any projectile speed